Inactivation of Protein-tyrosine Phosphatases as Mechanism of UV-induced Signal Transduction
نویسندگان
چکیده
منابع مشابه
Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction.
UV irradiation of cells causes ligand-independent activation of receptor tyrosine kinases. On the basis of dephosphorylation kinetics, UV-induced inactivation of receptor-directed tyrosine phosphatases (PTP) has been proposed as the mechanism of receptor activation (Knebel, A., Rahmsdorf, H. J., Ullrich, A., and Herrlich, P. (1996) EMBO J. 15, 5314-5325). Here we show that four defined protein-...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.37.26378